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KMID : 0620920010330010029
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Experimental & Molecular Medicine
2001 Volume.33 No. 1 p.29 ~ p.31
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F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients
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Yun Young Jung
Hong Il Ha/Soon Hee Jung/Min Goo Lee/Hyean Woo Lee/Joon Ho Yoon/Jong Whan Choi/Byung Il Yeh
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Abstract
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Mutations of the transmembrane conductance regulator (CFTR) gene in cystic fibrosis lead to dysfunction of the lung, pancreas, and sweat glands, etc. To investigate the possibility of the relationship between lung cancer and the mutations of CFTR gene, we determined amino acid sequences using reverse transcription-polymerase chain reaction (RT-PCR) and DNA sequencing. In this study, the deletion mutation of 508th amino acid in one of nine lung caner patients was found confirming that CFTR gene mutation exists in a Korean lung cancer patient.
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